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Thus, our study reveals that endometrial stromal cell ferroptosis in the ovarian endometrioma may trigger cytokine secretion and promote angiogenesis of adjacent lesions via paracrine actions to drive the development of endometriosis, providing a rationale for translation into clinical practice and developing drugs for endometriosis

Conversely, M2 microglia promote recovery by secreting anti-inflammatory factors like IL-10 and TGF-, controlling inflammation under hypoxic conditions and, consequently, preventing and treating neuroinflammatory diseases [50,51]

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