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Therefore, improvement of NOS dysfunction by BH 4 supplementation with sepiapterin probably involves both reversal of NOS uncoupling by replenishing BH 4 , and protection of the oxidase site by scavenging of peroxynitrite due to the antioxidant properties of BH 4

In keeping with this trend, serum IGF1 has been reported to increase in ND individuals after the initiation of insulin treatment [38]

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This stimulates the electron transport chain, which produces ATP, or energy, for the heart