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HAA are commonly abundant in globular proteins, where they are often buried in the protein core or shielded by lipid layers (Bera et al., 2018)

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MC3T3-E1 cells were treated with NAM in the presence or absence of 100 M H 2 O 2 during osteogenic differentiation for 4 or 10 days, and the medium was changed every other day (Supplementary Fig