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Improved regulation of CBF in response to both transient hyper- and hypotension subsequently protects cerebral microvasculature from hyperperfusive injury and damage as well as ensuring cerebral perfusion is able to match metabolic demand during periods of reduced driving pressures (i.e., orthostatic stress) (Claassen et al., 2021)

And the reason being is that we don't have to adapt anymore for the change of seasons because our our environment is totally controlled

Hong SJ, Kim SI, Kwon SM, et al

This could lead to increased cellular damage and accelerate the aging process, affecting the skin, organs, and overall health