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Teng (University of South Florida Morsani College of Medicine, Tampa, Florida, USA) 110

Consistent with this, the tau inclusions observed in our primary neuron seeding model showed colocalization between PAD-exposed tau, AT8, pS422 and oligomeric tau

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These modifications have been hypothesized to play a crucial role in the diffusion of DNA damage response/senescence-associated secretory phenotype (DDR/SAPS) signaling to non-damaged surrounding cells during aging, suggesting that DDR/SASP signaling components may contribute to the development of novel therapeutic interventions against age-related diseases (Olivieri et al., 2015)