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As previous international studies have noted, the true prevalence rate of restless legs syndrome may actually be underestimated due to a variety of factors, including the belief that restless legs are a minor ailment that doesn't require medical attention, the fear that affected individuals will be shunned in some cultures, and the absence of symptoms when testing a patient while they are awake (Yeh et al., 2016)

This diagram synthesizes key pathways, including anti-inflammatory, antioxidant, and anti-ferroptosis mechanisms

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Ital J Pediatr 45(1):36 Murai T, Matsuda S (2023) The chemopreventive effects of chlorogenic acids, phenolic compounds in coffee, against inflammation, cancer, and neurological diseases