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Given that ARID1A-negative cancer cells have been previously shown to be more susceptible to inhibition of glutathione synthesis compared to ARID1A-positive cancer cells, we next sought to determine whether EN25 selectively impairs cell viability of ARID1A-negative A2780 ovarian cancer cells, compared to ARID1A-positive RMG-1 ovarian cancer cells

IC, Interstitial cystitis

A recent 2022 study demonstrated that not only neurons but also glial cells rely on glutathione for homeostasis (12)

Gel band quantification was performed using Image J, and the apparent dissociation constant (K d ) was calculated by fitting binding curves in GraphPad Prism