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Complement complexes can be discovered in atherosclerotic lesions, and ECs exposed to complement are activated and improves the production of IL-6, IL-8 and MCP-1, thereby triggering the adhesion of monocytes to ECs 89

Yet B12 deficiency is remarkably common, affecting vegetarians, vegans, older adults, and anyone taking certain long-term medications like metformin or proton pump inhibitors

Funatsu H, Noma H, Mimura T et al (2009) Association of vitreous inflammatory factors with diabetic macular edema