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Oxidative stress response is clock dependent, as many of the antioxidant enzymes display circadian variations [48,49,50] and BMAL1 plays an important role in their regulation [51]

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These include reduced gonadotropin secretion due to impaired positive estrogen feedback on luteinizing hormone (LH) secretion in women (21), increased adrenal androgen secretion (22), and direct blockade of gonadotropin action at the gonadal level (23, 24)