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[118] Lee CK, Jeong SH, Jang C, et al

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By electron microscopy, sinusoidal endothelial cells and hepatocytes in the portal (zone 1) and midzonal (zone 2) areas were normal, as were hepatocytes in the central regions (zone 3)

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Additionally, chronic estradiol application promotes the expression of interleukin (IL)1, IL-6, IL-12p40, and Inducible nitric oxide synthase (iNOS) in macrophages following lipopolysaccharide (LPS) stimulation, further enhancing immune responses [105]

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