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One of the most critical pathways in this context is ferritinophagy, the autophagic degradation of ferritin, the cells primary iron-storage protein, to release free iron into the cytosol [102]

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Increased hypersensitivity to lidocaine, other amide local anaesthetics, a history of epileptiform convulsions with lidocaine, severe bradycardia, severe hypotension, cardiogenic shock, severe chronic heart failure (II-III degree), sick sinus syndrome, Wolff-Parkinson-White syndrome, Adams-Stokes syndrome, II and III degree atrioventricular (AV) block, hypovolemia, severe hepatic/renal impairment, porphyria, myasthenia

Additionally, this research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education (RS-2023-00245029)