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One in 4 cases is fatal and half of the survivors develop permanent neurological or psychiatric sequelae [1]

To address this, researchers often employ non-metabolic substrate analogues, such as -methylated amino acids (e.g., -methylleucine), which are recognized by transporters (e.g., LAT1) but cannot be incorporated into cellular metabolism (154, 155)

38 Total and free-reduced glutathione, oxidized glutathione (GSSG) and the total-reduced glutathione/GSSG and free-reduced glutathione/GSSG ratios were measured