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However, these results show that higher brain iron that occurs in AD is more pronounced when carrying the 4 genotype

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Without adequate levels of this master antioxidant, the entire cellular defense grid becomes compromised, leaving the body entirely vulnerable to both internal metabolic stress and external environmental toxins

30 The evidence suggests that NASH is a multifactorial process involving numerous conditions, including aberrations of lipid metabolism, oxidative and endoplasmic reticulum stress, insulin resistance, microbiota imbalance, immune responses, genetic susceptibility, and genomic instability