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Their design must strike a balance between ultra-high potency, sufficient chemical stability, and favorable physicochemical properties [91, 92]

Further, we consider the number of patients who will have a given set of characteristics and generally prefer not to create a new MS-DRG unless it would include a substantial number of cases

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Glutathione-S-transferase catalyzes the conjugation of NAPQI with GSH, forming APAP-GSH adducts, 9,10 which are further metabolized into nontoxic thiolate and cysteine molecules, including adducts of cysteamide, glycine/cysteine, and N-acetyl-L-cysteine