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The exact symptoms can differ based on which valve is affected, but they generally include: Abnormal heart murmur Irregular heartbeat Chest pain Shortness of breath, especially when lying down or after physical activity Fatigue Dizziness or fainting Abdominal swelling Swollen feet or ankles Preventing Cardiovascular Complications From Medication Patients with cardiovascular issues often take multiple medications, sometimes prescribed by several different clinicians, without considering the potential for drug interactions and filled by different pharmacists

In vivo micro-CT imaging The mice were anesthetized using 1% pentobarbital sodium, and pulmonary micro-CT imaging was performed using a Quantum GX system (PerkinElmer, USA)

(4) Availability of complete radiological and clinical follow-up data to assess therapeutic response to Everolimus

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