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Moreover, after caloric restriction, obese subjects showed weight loss together with ameliorated IR, reduced ER stress markers and improved mitochondrial function [53], suggesting the link between ER stress and abnormal lipid metabolism/IR

On the antioxidant hypothesis with regard to arteriosclerosis

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A separate study showed that TSA reduced Propionibacterium acnes-induced expression of pro-inflammatory factors (IL-1, IL-8, and TNF-) and activation of key proteins [TLR2, NF-B and intercellular adhesion molecule 1 (ICAM-1)] in the TLR2/NF-B signaling pathway in THP-1 cells, suggesting that TSA alleviates inflammation by blocking this pathway (41)