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Intestinal disorders and the loss of gut microbiota diversity impair the integrity of the intestinal barrier and can allow harmful microbial products, such as lipopolysaccharides, to enter the bloodstream, leading to systemic inflammation and metabolic disorders, which can weaken muscle function and reduce muscle mass (91) (Figure 3)

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Cholecystectomy promotes the development of colorectal cancer by the alternation of bile acid metabolism and the gut microbiota