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Routine early upper gastrointestinal series before starting diet is unhelpful in the absence of suspicious clinical signs, as it has been shown that it would change the clinical management of patients in only 0.8% of cases [25]

Riboflavin supplementationby increasing intracellular FAD concentrationcan restore cofactor binding, improve protein folding and subcellular localization, and rescue enzymatic activity, an effect known as the flavin chaperoning or chemical chaperone mechanism (58)

Thyroiditis (also known as chronic lymphocytic thyroiditis Chronic lymphocytic thyroiditis Hashimotos thyroiditis, or chronic lymphocytic thyroiditis, is the most common cause of hypothyroidism in iodine-sufficient regions

In addition, the incorporation of ICIs into neoadjuvant chemotherapy regimens has been shown to increase the pCR rate [43]