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Especially in the past half century, global warming has driven drier environment and higher water evaporation, as a result, leading to mucus thinning, epithelial compression and subsequent inflammation 289

New basic and clinical research is clarifying the mechanistic relevance and therapeutic feasibility of multiple targets within the glutamate system for novel drug discovery, including NMDA and AMPA (-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors, metabotropic glutamate receptors, and other key regulatory proteins such as glycine transporter 1 and excitatory amino acid transporters

J Biol Chem 287 , 44034410, doi: 10.1074/jbc.R111.283432 (2011)

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