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the clinical significance in humans remains under investigation and is not yet established for retatrutide specifically [24] [25] Other class-associated cautions: Based on the broader GLP-1/GIP receptor agonist class, potential effects on gallbladder function and delayed gastric emptying are relevant considerations, though evidence specific to retatrutide is still emerging It is important to note that this evidence derives from early-phase trials conducted under controlled conditions with medical supervision

However, later studies showed that it helped people quit smoking, so Bupropion has been FDA-approved to help with smoking cessation

The Practical Guide: Identification, Evaluation, and Treatment of Overweight and Obesity in Adults [online], (2000)

Last reviewed: 2026-05-29