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Analysis of clinical ovarian cancer samples ( n = 96) revealed that the methylation frequency of FBXO32 was 29.3% in patients with advanced disease, and this methylation status could independently predict poor survival [22]

In summary, we propose an integrated theoretical framework: under pathological conditions, VLDL transforms from a physiological immune regulator into a precursor of proinflammatory mediators, a lipotoxic agent, and a carrier with defective LPS clearance