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10.1001/jamacardio.2019.5954 [DOI] [PMC free article] [PubMed] [Google Scholar] 20

found that, under heat stress, HSF1 can promote the expression of Z-DNA binding protein 1 and then mediate RIP3-dependent necroptosis

This suggests that high levels of upstream lactate can override the limiting effect of p300, and it is more likely that p300 is not the sole writer of Hla and that other enzymes may be involved in this process, or even that p300 is not the primary writer for Kla (49)

It's a superhero of an antioxidant that our bodies produce in abundance, and it's brimming with all the good stuff we need to keep us feeling and looking young