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A seminal study published in Science demonstrated that plasma from exercised aged mice transfers enhanced adult hippocampal neurogenesis and cognition to sedentary aged recipients, identifying the liver enzyme GPLD1 as a key mediator whose systemic elevation recapitulates these benefits without entering the brain [32]

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Effects of (poly)phenols on cardiometabolic health: epidemiological evidence Currently, a significant number of meta-analyses focusing on observational studies investigating associations between (poly)phenols and health outcomes have been published