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Negreira et al., 2023), and mixed-genotype infections are frequently observed even within the same host tissue ( Leishmania is driven by several mechanisms, including mosaic aneuploidya common feature that enables rapid adaptation under stress, with non-random, strain-specific patterns indicating selective pressure (Sterkers et al., 2014

This creates a devastating feedback loop: the lack of glutathione allows oxidative stress to run rampant, which further impairs the methylation cycle, which in turn prevents the production of more glutathione