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coli1 5017, a significant synergistic effect was observed for the kanamycin and polymyxin B combination (FIC index = 0.42 0.05), thereby providing effective auxiliary validation for evaluating combination therapy efficacy

Acknowledgements Portions of the MS-based proteomics work described herein were performed at the Environmental Molecular Sciences Laboratory (grid.436923.9), a US Department of Energy (DOE) National Scientific User Facility located at the Pacific Northwest National Laboratory (PNNL)

B12 works synergistically with folate in cell division and gene expression, with deficiency potentially impairing folate metabolism

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