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doi: 10.1093/eurheartj/ehv305

however, there is a dearth of conclusive evidence in humans

The pose of the compounds regarding the functional groups at C4 was clear even from the beginning of the refinement for 1a R -IN-8, since the relative orientation of the methyl versus carboxymethyl groups could be decided based on unbiased maps even at the early stages of the refinement process