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Common research dose 300-500 mcg/day in research planning context, drawn from the dose range used across the published Phase 1/2 trials

Although there are alternative options of B12 supplemantation, such as oral pills, Vitamin B12 injections are the most effective delivery approach as they are best absorbed by th body since they bypass digestion by the stomach and intestines

Some patients feel as though they want more frequent injections, and occasionally we test levels to see if they are receiving adequate replacement, but Im not sure how strong the evidence is to support this. GPs should consider periodic vitamin B12 testing of higher-risk patients who take metformin, even if they dont display symptoms of deficiency, the UK medicines regulator said earlier this year