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Strategies targeting metabolic vulnerabilities will not only eliminate backup systems to prevent ferroptosis [49] , but also receive considerable attention in cancer therapeutics [54]

Therefore, current evidence and clinical guidelines support the early empirical supplementation of key nutrientsincluding water-soluble vitamins (B 1 , B 6 , folate), zinc, and fat-soluble vitaminseven in the absence of definitive laboratory confirmation [102]

The injection of a DNA vaccine expressing xCT proteins and immune targeting of xCT antigens on the cell surface effectively inhibited subcutaneous tumor growth and lung metastasis in mice and increased the chemosensitivity of breast CSCs to doxorubicin (44,83,92)

Interestingly, the epoxy-filled oblique cones (sensors 1 and 3) displayed superior light-guiding capabilities towards the LDRs compared to the hollow cones