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[5] Burckhardt CJ, Minna JD, Danuser G

Clinical studies have shown that moderate weight loss, defined as a 5-10% reduction of body weight is associated with a clinically meaningful improvement of metabolic risk factors, including improved pancreatic -cell function, and an increased insulin sensitivity of adipose tissue, liver and skeletal muscle (Magkos et al, 2016

Plasma concentrations decline approximately 60% between ages 20 and 60, making it a core subject of aging and regenerative research

That said, the insulated bottle kept our cold drinks cold even when we left it in the car on hot days of errands around town