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The follow-on open-label extension published by Steven Grinspoon and colleagues in 2010 and 2012 confirmed that the VAT reduction was maintained through 52 weeks of continuous dosing and that patients who switched from placebo to active compound at week 26 caught up to the original treatment arm by week 52

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As the DMSO concentration increased, there was also an increase in reduced glutathione and a progressive increase in membrane anisotropy (an inverse measure of membrane fluidity), explained as a reaction compensating for the pro-oxidant effects of DMSO on components of cytosol and cell membranes 27