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Other opioid-induced effects may include a reduction in biliary and pancreatic secretions, spasm of sphincter of Oddi, transient elevations in serum amylase, and opioid-induced esophageal dysfunction (OIED)

Additionally, diminished expression of soluble guanylate cyclase (sGC), the target of NO, in asthmatic airway epithelial cells leads to depletion of cGMP needed for bronchorelaxation (98)

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