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Coronary heart disease (CHD) is a globally prevalent cardiovascular disorder with a complex pathogenesis associated with multiple risk factors, including high-level low-density lipoprotein cholesterol, smoking, chronic kidney disease, diabetes and hypertension (1)

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The obtained results showed that in the cell group treated with Bi@Chi nanoparticles compared to the control group, there was no significant change in gap filling (cell migration) in 72 h, which could be caused by the chitosan (Chi) coating effect