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10 Reduced glutathione is associated with higher oxidative stress, 11 which contributes to damage 12 in the trabecular meshwork cells and retinal ganglion cells, worsening glaucoma and accelerating optic nerve damage

It attracts immune cells (macrophages and mast cells) to the site of damage, suppresses inflammatory cytokines (like TNF-alpha), and accelerates the closure of difficult-to-treat wounds, including diabetic ulcers and ischemic injuries

The DHS-led survival advantage of mice was accompanied by an increase in the total GPx activity as well as mRNA expression levels of seleno-GPxs ( GPx1 , GPx2 , GPx3 , and GPx4 ), reduction of lipid peroxidation, and suppression of inflammatory response (decrease of the expressions of pro-inflammatory genes and infiltration of inflammatory cells) in the radiosensitive organs such as spleen, intestine, and lung

Bellanti et al., 2022