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doi: 10.1002/bit.21256 27 LiuS.YiH.ZhanH.WangL.WangJ.LiY.et al

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This bidirectional regulation suggests sophisticated sensing of tissue microenvironmental cues, enabling GHK-Cu to normalize MMP activity toward homeostatic levels rather than exerting uniform stimulatory or inhibitory effects

Given that AMG 966 binds two trimeric targets and that each Fab domain is expected to bind one subunit of the trimer, we hypothesized that this robust anti-AMG 966 immune response was the consequence of immune complex formation