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Synthetic AGE inhibitors have largely failed to combat hyperglycemic and OS-related AGEs due to side effects, hence attention has switched to natural plant-based extracts (264)

TXNRD belongs to the pyridine nucleotide disulphide oxidoreductase family of enzymes and can reduce the oxidised form of Trx using NADPH as a co-substrate

A lower dose of 17 (2.5 ug/ml) displayed a higher effect on the cell viability under 640 nm-30mW

Importantly, we demonstrated that the ectopic expression of PLK2, independent of its kinase activity, in several types of cancer cells promoted the caspase-3 processing, GSDME cleavage, DAMPs release, and cell death, albeit without IL-1 secretion