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The C max values of each dose were 1.05 0.429, 3.30 0.508, and 26.1 7.82 ng/ml, respectively, and the AUC 0t values were 29.0 2.68, 160 21.0, and 830 247 ng min/mL respectively

Ketones are also critical for alleviating the toxicity of A, whereas -hydroxybutyrate reduces the toxicity of substance A42 in cultured hippocampal neurons and enables the cells to overcome amyloid-induced pyruvate dehydrogenase dysfunction [157]

An elastase-induced rat IA model was established as previously described, with in vivo measurements of aneurysm incidence, rupture rates, and artery structural integrity

Access this article Similar content being viewed by others Data availability The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request