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Adverse effects observed in trials to date include: Gastrointestinal symptoms nausea, vomiting, diarrhoea, and constipation (common with GLP-1 receptor agonists) Reduced appetite and weight loss , which may be excessive in some individuals Elevated heart rate , a concern noted with glucagon receptor agonism As with other incretin-based therapies, there is also a class-level signal for acute pancreatitis and gallbladder disease (including cholelithiasis and cholecystitis)

The pronounced effect on heat resistance of chitosan occurred on EHEC when combined with rutin or resveratrol in beef patties, due to the greater bacterial destruction from outer membrane to cytoplasmic membrane (Nair et al., 2016)

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A number of studies reported a slightly higher prevalence of allergic rhinitis in males than in females (Weeke, 1987)