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There are five different transcription factors under this family that get activated in the presence of pro-inflammatory cytokines, leading to the translocation of P65/P50 dimers stored in the cytoplasm to the nucleus activating cognate B motif, resulting in the expression of the NF-B target gene under the canonical pathway which has been extensively studied than noncanonical pathway activated by tumor necrosis factor (Wang et al., 2022)

Although anaerobes are by no means all harmless symbionts (the Bacteroidales and Clostridia mentioned before are all anaerobes), aerobes are more often associated with disease (Shoaie et al., 2021)

Freynhagen R, Baron R, Gockel U, Tolle TR

The genes it turns on are associated with collagen synthesis, wound healing, stem cell function, and DNA repair