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Fundamentally, DILI can be divided into two categories: intrinsic hepatotoxicity and idiosyncratic hepatotoxicity

We performed joint factorization of the transcriptomic and global proteomic data using multiomic factor analysis (MOFA) 27 and found that MOFA factors 1 and 2 captured the primitive versus committed and NPM1 mutation status (Extended Data Fig

The lack of AMPK inhibits the repair of intestinal epithelial cells (Olivier et al., 2022), and AMPK has been identified as a drug target for alleviating inflammatory bowel disease (IBD) in a rabbit model (Hwang et al., 2019)

The specific mechanisms remain under investigation, but the finding adds another dimension to DSIP's systemic regulatory effects