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Surprisingly, the decrease in GPX4 failed to damage the integrity of both neurons, and mice that only lost GPX4 in AgRP neurons experienced weight gain, while POMC neurons required for ROS buffering and metabolic homeostasis were unaffected by GPX4 deletion (129) ( Figure 2 )

It was found that insecticides of this group are able to bioaccumulate and persist in the environment after period of their use, which is due to the low bioavailability and ability of their residues to bind to the soil matrix (Hussain et al., 2016