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Serious hepatotoxicity at recommended or near recommended doses for therapeutic purposes has been reported in association with chronic alcohol use as chronic alcoholics are predispose to Paracetamol related toxicity at relatively low doses [7]

This confirms earlier reports that such interactions between GSH and metallothioneins occur, highlighting the relationship between these two compounds that depends on the cells redox state (Zalewska et al

After treatment of drug-resistant tumor cell lines, MCF7/TH, HCT116R and A549/ADR, with curcumin, ROS levels and expression of apoptotic markers, such as Bax and cytochrome c, were notably increased in the high-dose group compared to the low-dose group (25)