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A direct involvement of glycation in the development of age- and diabetic-related diseases Inevitably, the final consequences of the glycation of long-lived proteins (e.g., collagen, crystallin, or hemoglobin) are their loss of function and the development of glycation-related diseases, whose prevalence notably increases under hyperglycemic conditions

The pellet containing the mitochondrial fraction was resuspended in incubation buffer (120 mM KCl, 10 mM Tris, 5 mM KH 2 PO 4 , adjusted to pH 7.4 with HCl)

79 The ox-LDL inhibits the phosphorylation of phosphatidylinositol 3-kinase (PI3K) and Akt, leading to the redistribution and loss of nephrin