glutathione-s transferase gst addgene Glutathione-S-Transferase (GST)-Fusion Based Assays for Studying Protein-Protein Interactions Transglutaminase 2 crosslinks the glutathione

10.1016/j.cell.2016.11.018 148 SampsonT

Pharmacol Res 158:104844 Kamarajan P, Rajendiran TM, Kinchen J, Bermdez M, Danciu T, Kapila YL (2017) Head and neck squamous cell carcinoma metabolism draws on glutaminolysis, and stemness is specifically regulated by glutaminolysis via aldehyde dehydrogenase

Interestingly, the researchers found that lymphocytes in these patients had elevated levels of glutathione, which they hypothesize is a desperate, inadequate compensatory response by the cells trying to survive the relentless oxidative avalanche

A self-reinforcing cycle may develop Reduced mitochondrial efficiency may increase oxidative stress