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This receptor sensitization could contribute to the protein synthesis, cellular repair, and tissue regeneration outcomes observed across multiple preclinical models, from connective tissue to neural and smooth muscle

Biological changes occur at the cellular level before becoming visible

Compressed or irritated nerves create burning, shooting, or electric sensations that can travel down the legs

Preclinical studies document significant brain concentrations after systemic (including oral) administration, with behavioral improvements in hippocampal-dependent tasks confirming functionally relevant CNS penetration (PMID: 23055539)