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For example, mice overexpressing peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1) in skeletal muscle have increased BCAA catabolism (Tischler et al., 1982

Hallmayer J, Cleveland S, Torres A, Phillips J, Cohen B, Torigoe T et al

This article synthesizes clinical trial data from meta-analyses, Cochrane Reviews, and randomized controlled trials covering every major study on ALCAR with sample sizes, dosages, durations, and effect sizes

240,243-245 Several preclinical studies have shown PQQ may prevent the accumulation of damaging amyloid proteins such as beta-amyloid, 246-249 and might in this way protect against conditions such as Parkinsons disease and Alzheimers disease