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Mitochondria with absent cristae Optic atrophy (OPA): Other Leigh Syndrome 341 Nosology: Subacute necrotizing encephalomyelopathy Epidemiology: Prevalence 1:30,000 to 1:40,000 Leigh syndrome: Genetics Multiple causes Clinical spectrum with NARP Leigh syndrome: Clinical features Onset age Usual: 1 st 2 years

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