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In turn, enhancing KCC2 activity not only potentiated L838,417-induced analgesia, it rescued its analgesic potential at high doses, revealing a novel strategy for analgesia in pathological pain, by combined targeting of the appropriate GABA A R-subtypes and restoring Cl - homeostasis

The researchers concluded that with the almost complete lack of adverse effects, Pycnogenol is a good and efficacious alternative for MPH in childrens ADHD, especially in the school environment

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[DOI] [PubMed] [Google Scholar] Pacold ME, Brimacombe KR, Chan SH