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This is likely related to higher ROS production that cannot be balanced by the antioxidant systems

An important aspect of redox signaling is the localization of redox-active processes within distinct microenvironments of the cell, and redox-active endosomes (redoxosomes) are one key example of this

Conventional treatments, such as Nonsteroidal Anti-Inflammatory Drugs (NSAIDs), often fail because they target inflammation, which is largely absent in chronic tendinosis