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The heart, in particular, depends on a continuous and substantial supply of ATP to maintain its function, which is why CoQ10 has been one of the most studied supplements in the context of cardiovascular support.* CoQ10 levels naturally decline with age

Furthermore, the 4.7 kb single-stranded packaging capacity limit of AAV vectors precludes direct delivery of the SCN1A gene encoding Nav1.1 (approximately 6 kb), as DNA fragments exceeding this capacity lead to vector packaging failure or functional loss

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Propionylcarnitine excretion in propionic acid and methylmalonic acidurias: a cause of carnitine deficiency