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Some research suggests splitting the dose (e.g., 1,000 mg in the morning with breakfast + 1,000 mg pre-workout) produces better muscle carnitine accumulation than a single large dose

Functional imaging of brown fat in mice with 18F-FDG micro-PET/CT

BMC Oral Health 24, 245

70 The effectiveness of melatonin supplementation for promoting sleep in healthy people has been demonstrated using doses as low as 0.1 mg and up to 6 mg